[1]杨静,乔海灵.青霉素特异性IgE抗体的种类与HLADRB基因多态性[J].中国药理学通报,2008,(06):0.
 YANG Jing,QIAO Hai ling.Correlation of HLADRB genetic locus with penicillinspecific IgE antibodies[J].Chinese Pharmacological Bulletin,2008,(06):0.
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青霉素特异性IgE抗体的种类与HLADRB基因多态性()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2008年06期
页码:
0
栏目:
论著
出版日期:
2008-06-25

文章信息/Info

Title:
Correlation of HLADRB genetic locus with penicillinspecific IgE antibodies
作者:
杨静乔海灵
郑州大学临床药理研究所,河南 郑州450052
Author(s):
YANG JingQIAO Hailing
Institute of Clinical Pharmacology,Zhengzhou University,Zhengzhou450052,China
关键词:
过敏反应青霉素基因多态性HLADRBIgE
Keywords:
allergypenicillingenetic polymorphismHLADRBIgE
分类号:
R 39211;R 3922;R 3942;R 5931
文献标志码:
A
摘要:
目的探讨HLADRB基因是否调控青霉素过敏反应产生不同种类的IgE抗体。方法以河南汉族临床青霉素过敏反应的病人为研究对象,采用放射免疫吸附试验(radio allergosorbent test,RAST)检测血清中针对青霉素药物的8种特异性IgE抗体和采用序列特异性引物聚合酶链反应(polymerase chain reaction sequencespecific primer,PCRSSP)的方法检测HLADRB等位基因。结果80例抗体阳性病人中,BPO、BPA、PVO、PVA、APO、APA、AXO、AXAIgE阳性的分别为36、33、32、29、21、12、16、33例。与对照组相比,BPOIgE阳性组DR16基因和PVO阳性组DR14.1基因明显降低(0 vs 862%,P<001;156% vs 977%,P<005)。结论DR16基因可能与BPO抗原的过敏有关,DR141基因可能与PVO抗原的过敏有关。
Abstract:
AimTo explore the correlation of positive specific IgE antibodies with penicillin allergy and HLADRB genetic polymorphism.MethodsSequence specific primerpolymerase chain reaction (PCRSSP) was used to type human leucocyte antigenDBR(HLADRB) alleles in 80 patients with positive IgE antibodies to penicillin and 101 healthy subjects without any allergic reactions.ResultsWhen different penicillin antigens were analyzed separately,the gene frequencies of DR16 in patients with positive BPOIgE antibody and DR14.1 in patients with positive PVOIgE antibody were found greatly lower than those of the control subjects( 0 vs 862%,P<001;156% vs 977%,P<005).ConclusionsDR16 gene and allergy to BPO antigen were correlated, and the same was true between DR141 gene and allergy to PVO antigen.

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备注/Memo

备注/Memo:
收稿日期:2008-02-20,修回日期:2008-03-25基金项目:河南省杰出青年基金资助项目(No 0312002100);河南省自然科学基金资助项目(No 0211040100);河南省医学创新人才工程资助项目(No 2002114)作者简介:杨静(1977-),女,博士,讲师,研究方向:药物过敏反应和药代动力学;乔海灵(1963-),男,博士,教授,博士生导师,研究方向:药物过敏反应和药代动力学,通讯作者,Tel/Fax:037166658190,Email:qiaohl@zzu.edu.cn
更新日期/Last Update: 2008-06-15