[1]董世芬,张胜威,孙建宁.沉默信息调节因子2同源蛋白1(SIRT1)与阿尔茨海默病研究进展[J].中国药理学通报,2016,(08):1041-1044.[doi:10.3969/j.issn.1001-1978.2016.08.002]
 DONG Shi-fen,ZHANG Sheng-wei,SUN Jian-ning.Silent mating-type information regulator 2 homolog 1 (SIRT1)in Alzheimer's disease:an update on potential mechanisms[J].Chinese Pharmacological Bulletin,2016,(08):1041-1044.[doi:10.3969/j.issn.1001-1978.2016.08.002]
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沉默信息调节因子2同源蛋白1(SIRT1)与阿尔茨海默病研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2016年08期
页码:
1041-1044
栏目:
讲座与综述
出版日期:
2016-08-15

文章信息/Info

Title:
Silent mating-type information regulator 2 homolog 1 (SIRT1)in Alzheimer's disease:an update on potential mechanisms
文章编号:
1001-1978(2016)08-1041-04
作者:
董世芬1张胜威12孙建宁1
1.北京中医药大学中药学院中药药理系,北京 100102;
2. 河南中医药大学第一附属医院消化科,河南 郑州 450004
Author(s):
DONG Shi-fen1 ZHANG Sheng-wei12 SUN Jian-ning1
1. Dept of Pharmacology, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102;
2. Dept of Gastroenterology, the First Affiliated Hospital of Henan University of TCM, Zhengzhou 450004,China
关键词:
阿尔茨海默病 沉默信息调节因子2同源蛋白1 Akt/蛋白激酶B β淀粉样蛋白沉积 tau蛋白磷酸化 突触可塑性
Keywords:
Alzheimer's disease silent mating-type information regulator 2 homolog 1 Akt/ protein kinase B amyloid-β aggregation tau protein phosphorylation synaptic plasticity
分类号:
R-05;R341;R345.57;R394;R745.7;R977.6
DOI:
10.3969/j.issn.1001-1978.2016.08.002
文献标志码:
A
摘要:
沉默信息调节因子2同源蛋白1(SIRT1)激动可通过抑制β淀粉样蛋白沉积、tau蛋白磷酸化、炎症反应,调节突触可塑性,以及与Akt/蛋白激酶B通路共同作用,改善阿尔茨海默病(AD)的认知功能障碍。该文就SIRT1与AD研究进展进行综述。
Abstract:
Alzheimer's disease(AD)is characterized by progressive loss of memory and other cognitive functions. With recent discoveries, activation of silent mating-type information regulator 2 homolog 1(SIRT1)could attenuate the cognitive dysfunction of AD via reducing amyloid-β aggregation and tau protein phosphorylation, inhibiting inflammatory reaction, and regulating synaptic plasticity. This review aims to highlight the involvement of these new discoveries of SIRT1, and Akt/protein kinase B(PKB)signaling pathways, for their potential therapeutic effect against AD.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金资助项目(No 81503287); 教育部博士点基金资助项目(No 20130013120002); 北京优博项目(No YB20101002601)
作者简介:董世芬(1983-),女,博士,讲师,研究方向:中药防治心脑血管疾病,Tel:010-84738627,E-mail:tedong4444@gmail.com;
孙建宁(1952-),女,教授,博士生导师,研究方向:中药防治心脑血管疾病,通讯作者,E-mail:jn_sun@sina.com
更新日期/Last Update: 2016-08-15