LUO Xiao-ya,YANG Zhi-hong.Research progress on correlation between intestinal flora and cardiovascular diseases[J].Chinese Pharmacological Bulletin,2018,(08):1037-1041.[doi:10.3969/j.issn.1001-1978.2018.08.001]





Research progress on correlation between intestinal flora and cardiovascular diseases
中国医学科学院北京协和医学院药用植物研究所药理毒理中心,北京 100193
LUO Xiao-ya YANG Zhi-hong
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College; Center of Pharmacology and Toxicology, Beijing 100193,China
肠道菌群 紊乱 心血管疾病 相关性 干预治疗 研究进展
intestinal flora disorder cardiovascular disease relevance intervention therapy research progress
R-05; R322.45; R378.2; R540.5
The variation in the hemodynamics of patients with cardiovascular diseases can change intestinal morphology, intestinal permeability, intestinal barrier function and intestinal flora composition.The changes can further damage the intestinal tract, resulting in intestinal flora disorders, metabolic destruction, enhancement of oxidative stress and exacerbation of systemic inflammation.Meanwhile, metabolites via intestinal flora also have a possible regulatory mechanism for the pathophysiology of cardiovascular diseases.In the review, the relevant literatures in recent 16 years concerning the interactive relationship between intestinal flora and cardiovascular diseases and treatment of cardiovascular diseases through intestinal flora have been collected, in order to provide a theoretical reference for treatment of cardiovascular diseases via intestinal flora.


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基金项目:国家自然科学基金资助项目(No 81473579,81273654,81102879); 北京市自然科学基金资助项目(No 7173267); 国家科技部“重大新药创制”科技重大专项(No 2013ZX09103002-022)
更新日期/Last Update: 2018-07-26