[1]郑卓玲,黄 民,李嘉丽.麻醉药物及其辅助药物基因组学的研究进展[J].中国药理学通报,2018,(08):1049-1052.[doi:10.3969/j.issn.1001-1978.2018.08.004]
 ZHENG Zhuo-ling,HUANG Min,LI Jia-li.Advances in research on pharmacogenomics of anesthetics and their adjuvants[J].Chinese Pharmacological Bulletin,2018,(08):1049-1052.[doi:10.3969/j.issn.1001-1978.2018.08.004]
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麻醉药物及其辅助药物基因组学的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年08期
页码:
1049-1052
栏目:
讲座与综述
出版日期:
2018-08-26

文章信息/Info

Title:
Advances in research on pharmacogenomics of anesthetics and their adjuvants
文章编号:
1001-1978(2018)08-1049-04
作者:
郑卓玲黄 民李嘉丽
中山大学药学院临床药理研究所,广东 广州 510080
Author(s):
ZHENG Zhuo-ling HUANG Min LI Jia-li
Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510080,China
关键词:
麻醉药 药物基因组学 遗传 个体化用药 代谢酶 丙泊酚
Keywords:
anesthetics pharmacogenomics genetic personalized medicine metabolic enzyme propofol
分类号:
R-05; R394.6; R971.2; R977.3
DOI:
10.3969/j.issn.1001-1978.2018.08.004
文献标志码:
A
摘要:
麻醉药及其辅助药物是外科手术的必备药物,然而在临床常规治疗方案下,药物反应具有明显的个体差异。遗传因素是造成个体间药代动力学、药效学反应差异的重要原因。现对国内外麻醉药及其辅助药物的基因组学研究进展进行综述,为麻醉药物的个体化用药提供参考。
Abstract:
Anesthetics and its adjuvant drugs are essential for surgery, but their drug reactions have significant individual difference in the clinical routine treatment program.Genetic polymorphism is an important influencing factor of individual differences in the pharmacokinetics and pharmacodynamics of drugs.This paper presents an overview of the research progress of pharmacogenomics of anesthetics and their adjuvant drugs at home and abroad.

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备注/Memo

备注/Memo:
收稿日期:2018-04-22,修回日期:2018-05-27
基金项目:国家重点研发计划项目(No 2017YFC0909303, 22016 YFC0905001); “十二五”国家科技重大专项资助项目(No 2012ZX09506001-004); 广东省重点实验室建设项目(No 2011A060901014); 广东省重大科技专项(No 2011A080300001, 2012A080202013)
作者简介:郑卓玲(1993-),女,硕士生,研究方向:药代动力学与药物基因组学,Tel:020-87331409,E-mail: zhengzhl3@mail2.sysu.edu.cn;
李嘉丽(1982-),女,博士,副教授,硕士生导师,研究方向:临床药理学、药物代谢与药物基因组学,通讯作者,Tel:020-39943034,E-mail:lijiali5@mail.sysu.edu.cn
更新日期/Last Update: 2018-07-26