[1]肖 轩,等.铁稳态及黄酮类化合物对其调控的研究进展[J].中国药理学通报,2018,(08):1053-1057.[doi:10.3969/j.issn.1001-1978.2018.08.005]
 XIAO Xuan,NIU Yin-bo,YANG Yuan-yuan,et al.The research progress of iron homeostasis and flavonoids in its regulation[J].Chinese Pharmacological Bulletin,2018,(08):1053-1057.[doi:10.3969/j.issn.1001-1978.2018.08.005]
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铁稳态及黄酮类化合物对其调控的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年08期
页码:
1053-1057
栏目:
讲座与综述
出版日期:
2018-07-26

文章信息/Info

Title:
The research progress of iron homeostasis and flavonoids in its regulation
文章编号:
1001-1978(2018)08-1053-05
作者:
肖 轩1 2牛银波123杨园园1 2董 栋12李京宝123商 澎23
1.西北工业大学生命学院,陕西 西安 710072; 2.空间生物实验模拟技术国防重点学科实验室,陕西 西安 710072; 3.西北工业大学深圳研究院,广东 深圳 518057
Author(s):
XIAO Xuan12 NIU Yin-bo123 YANG Yuan-yuan12 DONG Dong12 LI Jing-bao123 SHANG Peng23
1.School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China; 2.Key Lab for Space Bioscience & Biotechnology, Xi'an 710072, China; 3.Research & Development Institute in Shenzhen, Northwestern Polytechnical University, Shenzhen Guangdong 518057,China
关键词:
铁稳态 黄酮类化合物 铁过载 铁缺乏 铁调控 细胞内铁稳态 系统性铁稳态
Keywords:
iron homeostasis flavonoids iron overload iron deficiency iron regulation cellular iron homeostasis systemic iron homeostasis
分类号:
R-05; R282.71; R312; R348.4; R591.1
DOI:
10.3969/j.issn.1001-1978.2018.08.005
文献标志码:
A
摘要:
铁在人体许多必需的生化过程中起着重要作用,然而许多研究表明,铁稳态失衡与机体多种疾病的发生密切相关。基于铁稳态失衡的致病机制和黄酮类化合物可螯合铁的结构特点,该文主要对铁稳态及黄酮类化合物对其调控的研究进展进行综述,为将黄酮类化合物开发为防治铁稳态失衡性疾病的药物提供参考。
Abstract:
Iron plays an important role in many essential biochemical processes of the human body, but many studies show that the imbalance of iron homeostasis is closely related to the occurrence of multiple diseases in the body.Based on the pathogenesis of imbalanced iron homeostasis and the structural characteristics of flavonoids chelating iron, this paper summarizes the research progress of iron homeostasis and flavonoids in its regulation, in order to provide a reference for the development of flavonoids as drugs for preventing the imbalance of iron homeostasis.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2018-04-16,修回日期:2018-05-24
基金项目:国家自然科学基金面上项目(No 51477141); 陕西省自然科学基础研究计划(No 2016JQ8005); 深圳市知识创新计划学科布局项目(No JCYJ20170412140904406); 中央高校基本科研业务费专项资金资助(No 3102017zy051)
作者简介:肖 轩(1994-),女,硕士生,研究方向:骨代谢与铁代谢,E-mail:xiaoxuanxuan@mail.nwpu.edu.cn;
商 澎(1964-),男,博士,教授,博士生导师,研究方向:骨代谢与铁代谢,通讯作者,E-mail:shangpeng@nwpu.edu.cn
更新日期/Last Update: 2018-07-26