[1]张贤政,邰 宇,张玲玲,等.基因多态性对类风湿关节炎药物疗效和不良反应影响的研究进展[J].中国药理学通报,2018,(09):1193-1198.[doi:10.3969/j.issn.1001-1978.2018.09.003]
 ZHANG Xian-Zheng,TAI Yu,ZHANG Ling-ling,et al.Advances of gene polymorphism affecting rheumatoid arthritis drug efficacy and adverse drug reactions[J].Chinese Pharmacological Bulletin,2018,(09):1193-1198.[doi:10.3969/j.issn.1001-1978.2018.09.003]
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基因多态性对类风湿关节炎药物疗效和不良反应影响的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年09期
页码:
1193-1198
栏目:
讲座与综述
出版日期:
2018-09-26

文章信息/Info

Title:
Advances of gene polymorphism affecting rheumatoid arthritis drug efficacy and adverse drug reactions
文章编号:
1001-1978(2018)09-1193-06
作者:
张贤政邰 宇张玲玲魏 伟
安徽医科大学临床药理研究所,抗炎免疫药物教育部重点实验室,安徽省高校抗炎免疫药物协同创新中心,安徽省高校抗炎免疫药物创新团队,安徽 合肥 230032
Author(s):
ZHANG Xian-Zheng TAI Yu ZHANG Ling-ling WEI Wei
Institute of Clinical Pharmacology, Anhui Medical University, Key Lab of Anti-inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-inflammatory and Immune Medicine, Anhui Anti-inflammatory and Immune Medicine Innovation Team, Hefei 230032, China
关键词:
基因多态性 类风湿关节炎 药物 代谢 疗效 不良反应
Keywords:
gene polymorphism rheumatoid arthritis drugs metabolism efficacy adverse reactions
分类号:
R-05; R392.11; R392.12; R394.2; R593.220.5
DOI:
10.3969/j.issn.1001-1978.2018.09.003
文献标志码:
A
摘要:
治疗类风湿关节炎(rheumatoid arthritis, RA)的药物主要包括疾病调修抗风湿药物(disease-modifying antirheumatic drugs, DMARDs)、非甾体抗炎药物(nonsteroidal anti-inflammatory drugs, NSAIDs)、生物制剂等。这些药物对于阻止RA病程和预防并发症起着重要作用,但是药物疗效和不良反应在RA患者中存在个体差异。编码药物代谢酶(二氢叶酸还原酶、细胞色素P450酶、N-乙酰转移酶等)、药物转运蛋白(ATP结合盒转运蛋白等)和药物靶点(肿瘤坏死因子-α受体等)的基因存在多态性。药物转运蛋白基因多态性可改变药物的分布、排泄,药物靶标的多态性明显影响药物的敏感性。这些基因多态性会影响药物代谢动力学和药效学,也可能是导致个体间药物疗效和不良反应差异的重要机制。该文系统综述了基因多态性对RA药物疗效和不良反应的影响。
Abstract:
Drugs for the treatment of rheumatoid arthritis(RA)include disease-modifying antirheumatic drugs(DMARDs), nonsteroidal anti-inflammatory drugs(NSAIDs)and biological agents, etc. These drugs are critical in preventing the process and complications of RA. However, the outcome of treatment and adverse drug reactions with these drugs in RA patients are different individually. Drug-metabolizing enzymes(dihydrofolate reductase, cytochrome P450enzymes, N-acetyltransferases, and so on.), drug transporters(ATP-binding cassette transporters)and drug targets(tumor necrosis factor-α receptors)are coded for by variant alleles. The gene polymorphism of drug transporters can change the distribution and excretion of drugs. The polymorphisms of drug target affect significantly drug sensitivity. These gene polymorphisms may influence the pharmacokinetics, pharmacodynamics and side effects of medicine. In this article, we review the genetic polymorphisms that affect the efficacy of drug or the occurrence of adverse drug reactions in RA.

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备注/Memo

备注/Memo:
收稿日期:2018-04-20,修回日期:2018-05-16
基金项目:国家自然科学基金资助项目(No 81330081, 81473223, 81673444)
作者简介:张贤政(1993-),男,硕士生,研究方向:自身免疫病学及抗炎免疫药理学,E-mail:404450083@qq.com;
邰 宇(1994-),女,硕士生,研究方向:自身免疫病学及抗炎免疫药理学,共同第一作者,E-mail:378292111@qq.com;
张玲玲(1972-),女,博士,教授,博士生导师,研究方向:自身免疫病学及抗炎免疫药理学,通讯作者,E-mail:llzhang@ahmu.edu.cn;
魏 伟(1960-),男,博士,教授,博士生导师,研究方向:自身免疫病学及抗炎免疫药理学,通讯作者,E-mail:wwei@ahmu.edu.cn
更新日期/Last Update: 2018-08-26