[1]张国荣,刘 楠,徐 洋,等.感染加重慢性呼吸道疾病的小鼠模型研究进展[J].中国药理学通报,2018,(09):1199-1202.[doi:10.3969/j.issn.1001-1978.2018.09.004]
 ZHANG Guo-rong,LIU Nan,XU Yang,et al.Murine models of infectious exacerbation of respiratory disease[J].Chinese Pharmacological Bulletin,2018,(09):1199-1202.[doi:10.3969/j.issn.1001-1978.2018.09.004]
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感染加重慢性呼吸道疾病的小鼠模型研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年09期
页码:
1199-1202
栏目:
讲座与综述
出版日期:
2018-08-26

文章信息/Info

Title:
Murine models of infectious exacerbation of respiratory disease
文章编号:
1001-1978(2018)09-1199-04
作者:
张国荣12刘 楠12徐 洋12刘 莉123
1.中国医药工业研究总院药理评价研究中心,上海 200040; 2.上海医药工业研究院创新药物与 制药工艺国家重点实验室,上海 200437; 3.上海市生物物质成药性评价专业技术服务平台,上海 200437
Author(s):
ZHANG Guo-rong12 LIU Nan12 XU Yang12 LIU Li123
1.China State Institute of Pharmaceutical Industry, Shanghai 200040, China; 2.State Key Lab of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China; 3.Shanghai Professional and Technical Service Center for Biological Material Druggability Evaluation, Shanghai 200437,China
关键词:
哮喘 慢性阻塞性肺病 肺部囊性纤维化 细菌 病毒 小鼠模型
Keywords:
asthma chronic obstructive pulmonary disease cystic fibrosis bacteria virus murine models
分类号:
R-05; R363-332; R373.1; R378.991; R562.25; R563.9
DOI:
10.3969/j.issn.1001-1978.2018.09.004
文献标志码:
A
摘要:
哮喘、慢性阻塞性肺病(chronic obstructive pulmonary disease,COPD)和肺部囊性纤维化(cystic fibrosis,CF)是3种常见的慢性呼吸道疾病,有证据表明,呼吸道疾病的恶化与呼吸道病毒和细菌的感染相关。综合目前的研究发现,生命早期的呼吸道感染会改变机体的免疫反应和肺部结构,从而加重哮喘,成年期感染甚至会使哮喘患者抵抗类固醇的治疗。COPD患者呼吸道感染会加重肺部炎症和气道重塑水平。呼吸道铜绿假单胞菌感染会诱导和加重肺部CF。然而,目前尚缺乏有效的治疗措施能够阻止或逆转感染诱导的呼吸道疾病恶化,所以,需要建立能够模拟人类疾病特征的小鼠模型,帮助研究感染在疾病恶化中的作用。该文对近年来关于感染加重呼吸道疾病的小鼠模型研究进展进行综述,重点概述通过小鼠模型发现的3种呼吸道疾病的病理改变,并探讨基于这些小鼠模型可以发展和验证的治疗方法,为后续的呼吸道疾病研究和临床治疗提供参考。
Abstract:
Asthma, chronic obstructive pulmonary disease(COPD), cystic fibrosis(CF)lung disease are common chronic respiratory diseases. There has been evidence that respiratory infections with bacteria and viruses underpin the pathogenesis of the respiratory diseases. It is now well-recognized that early life infections may induce more severe asthma by inducing permanent alterations in immunity and lung structure, and even induce steroid-resistant severe asthma in adulthood. Respiratory infections will exacerbate the inflammation and remodeling in lung of COPD. P. aeruginosa infection in lung will induce CF. There are no effective therapies preventing or reversing the exacerbation of respiratory diseases. The development and use of mouse models are proved to be valuable in understanding the role of infection in disease pathogenesis. This article reviews the progresses in murine models of infectious exacerbation of respiratory diseases, emphasizes on the pathological changes of the three respiratory diseases found with the application of murine models, and explores the therapeutic method which can be developed and tested by the application of murine models, in order to offer reference for clinical research and treatment.

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备注/Memo

备注/Memo:
收稿日期:2018-03-25,修回日期:2018-05-22
基金项目:上海市生物物质成药性评价专业技术服务平台(No 15DZ2291700)
作者简介:张国荣(1994-),女,硕士生,研究方向:中药药理学,E-mail:zhangguorong77777@163.com;
刘 莉(1967-),女,博士,研究员,博士生导师,研究方向:中药药理学、免疫药理学、消化药理学,通讯作者,E-mail: liuli1129@hotmail.com
更新日期/Last Update: 2018-08-26