[1]赵海洲,李 军,马延红,等.Parkin共调基因调控功能与疾病研究进展[J].中国药理学通报,2018,(10):1333-1336.[doi:10.3969/j.issn.1001-1978.2018.10.001]
 ZHAO Hai-zhou,LI Jun,MA Yan-hong,et al.Research progress of Parkin co-regulated gene[J].Chinese Pharmacological Bulletin,2018,(10):1333-1336.[doi:10.3969/j.issn.1001-1978.2018.10.001]
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Parkin共调基因调控功能与疾病研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年10期
页码:
1333-1336
栏目:
讲座与综述
出版日期:
2018-09-26

文章信息/Info

Title:
Research progress of Parkin co-regulated gene
文章编号:
1001-1978(2018)10-1333-04
作者:
赵海洲李 军马延红刘文华
肇庆学院生命科学学院,广东 肇庆 526061
Author(s):
ZHAO Hai-zhou LI Jun MA Yan-hong LIU Wen-hua
School of Life Sciences, Zhaoqing University, Zhaoqing Guangdong 526061,China
关键词:
PACRG 鞭毛 纤毛 帕金森病 麻风病 癌症
Keywords:
PACRG flagellum cilia Parkinson's disease leprosy cancer
分类号:
R-05; R394.2; R521; R730.261; R733.7; R737.11; R742.5; R745.702.6; R755
DOI:
10.3969/j.issn.1001-1978.2018.10.001
文献标志码:
A
摘要:
Parkin共调基因(PACRG)与帕金森病相关基因Parkin共表达,共用一个双向启动子。它与微管蛋白的功能关系密切,通过微管蛋白调节鞭毛、纤毛的运动,参与精子发育,还能够减弱Parkin底物的毒性作用,增加细胞成活率。SNP分析结果显示,PACRG与麻风病、伤寒副伤寒、癌症、肺结核等疾病的发生具有相关性。该文对PACRG基因调控功能和相关疾病研究进展做一综述。
Abstract:
The Parkin co-regulated gene(PACRG)was expressed in conjunction with Parkinson's disease-associated gene Parkin due to a bi-directional promoter shared by PACRG and Parkin.PACRG is closely related to the function of microtube protein by which it regulates the movement of flagella and cilia and participates in the development of sperm.PACRG can also weaken the toxicity of a substrate of Parkin and increase cell viability.SNP analysis showed that PACRG was correlated with the occurrence of leprosy, typhoid fever, paratyphoid fever, cancer and tuberculosis.This review summarizes the research progress of PACRG in regulative function and relevant diseases.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2018-06-18,修回日期:2018-07-25
基金项目:广东省教育厅重大项目(No 2014KZDXM075); 广东省教育厅创新团队项目(No 2015KCXTD032); 广东省教育厅青年创新人才项目(No 2016KQNCX178)
作者简介:赵海洲(1987-),男,硕士,研究实习员,研究方向:神经生物学,E-mail:zhaohaizhou012@163.com;
刘文华(1967-),男,博士,教授,硕士生导师,研究方向:神经生物学,通讯作者,E-mail:wenhualiu@hotmail.com
更新日期/Last Update: 2018-09-26