[1]王 敏,余 薇,查文良.自噬和线粒体自噬在糖尿病心肌病中的作用研究进展[J].中国药理学通报,2018,(10):1337-1340.[doi:10.3969/j.issn.1001-1978.2018.10.002]
 WANG Min,YU Wei,ZHA Wen-liang.Research progress of autophagy and mitochondrial autophagy in diabetic cardiomyopathy[J].Chinese Pharmacological Bulletin,2018,(10):1337-1340.[doi:10.3969/j.issn.1001-1978.2018.10.002]





Research progress of autophagy and mitochondrial autophagy in diabetic cardiomyopathy
王 敏余 薇查文良
湖北科技学院药学院,湖北 咸宁 437100
WANG Min YU Wei ZHA Wen-liang
School of Pharmacy, Hubei University of Science and Technology, Xianning Hubei 437100, China
糖尿病心肌病 氧化应激 自噬 线粒体自噬 凋亡 AMPK mTORC1 Parkin PINK1 NIX
diabetic cardiomyopathy oxidative stress autophagy mitophagy apoptosis AMPK mTORC1 Parkin PINK1 NIX
R-05; R329.24; R542.2; R587.1; R587.2
In recent years, due to the aging of society and a rising incidence of obesity rate, the number of diabetic patients is rising year by year.Approximately, more than half of the diabetic patients died from cardiovascular complications of diabetes.Abundant in heart, mitochondria serve as energy resources, so its dysfunction may contribute to myocardial cell damage.Hyperglycemia can cause damage to the inner mitochondria of heart muscle, thus timely and effective degradation of damaged mitochondria reduces the incidence of diabetic cardiomyopathy.Mitophagy can remove dysfunctional mitochondria, control mitochondrial mass and ensure environmental stability in cells.In this review, we summarize the role of autophagy and mitophagy in diabetic cardiomyopathy via introducing some proteins and pathways involved in mitophagy.


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基金项目:国家自然科学基金资助项目(No 81500296); 湖北科技学院临床医学重点(培育)学科专项基金(No LCZX201506); 湖北科技学院药学重点学科专项科研项目(2018-19XZY17)
作者简介:王 敏(1994-),女,硕士生,研究方向:心血管药理学,E-mail:254332190@qq.com;
更新日期/Last Update: 2018-08-26