[1]姚 瑶,黄 成,李 俊.PSTPIP2在自身炎症性疾病中的研究进展[J].中国药理学通报,2018,(10):1341-1344.[doi:10.3969/j.issn.1001-1978.2018.10.003]
 YAO Yao,HUANG Cheng,LI Jun.Research progress of PSTPIP2 in autoinflammatory disease[J].Chinese Pharmacological Bulletin,2018,(10):1341-1344.[doi:10.3969/j.issn.1001-1978.2018.10.003]
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PSTPIP2在自身炎症性疾病中的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年10期
页码:
1341-1344
栏目:
讲座与综述
出版日期:
2018-09-26

文章信息/Info

Title:
Research progress of PSTPIP2 in autoinflammatory disease
文章编号:
1001-1978(2018)10-1341-04
作者:
姚 瑶123黄 成123李 俊123
1.安徽医科大学药学院,安徽省重大自身免疫性疾病重点实验室,安徽省创新药物产业共性技术研究院; 2.抗炎免疫药物教育部重点实验室; 3.安徽医科大学肝病研究所,安徽 合肥 230032
Author(s):
YAO Yao123HUANG Cheng123LI Jun123
1.School of Pharmacy, Anhui Medical University, Key Lab of Major Autoimmune Diseases in Anhui Province,Research Institute of General Technology of Innovative Pharmaceutical Industry in Anhui Province; 2.Key Lab of Anti-inflammatory and Immunologic drugs, Ministry of Education; 3.Institute of Hepatology, Anhui Medical University, Hefei 230032,China
关键词:
PSTPIP2 自身炎症性疾病 破骨细胞 巨噬细胞 生物学功能 作用机制
Keywords:
PSTPIP2 autoinflammatory disease osteoclast macrophage biological functions molecular mechanism
分类号:
R-05; R329.24; R341; R364.5; R442.8; R593.2; R596
DOI:
10.3969/j.issn.1001-1978.2018.10.003
文献标志码:
A
摘要:
脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2(PSTPIP2),是一种骨架蛋白,位于细胞膜上,参与自身炎症性疾病的发生、发展。在先天性免疫和自身炎症性疾病中发挥着重要的作用。在自身炎症性疾病中,PSTPIP2属于F-BAR蛋白家族,可以参与抑制炎症反应、巨噬细胞活化、中性粒细胞运动和破骨细胞分化。PSTPIP2还可以与SHIP1和CSK结合,从而抑制自身炎症性疾病的发生、发展。该文就PSTPIP2在自身炎症性疾病中的研究进展及其功能进行综述。
Abstract:
Proline-serine-threonine phosphatase-interacting protein 2(PSTPIP2), is a scaffold protein located on the cell membrane involved in the development and progression of autoinflammatory diseases.It plays an important role in innate immunity and autoinflammatory diseases.In autoinflammatory diseases, PSTPIP2 can be involved in the inhibition of inflammatory reactions, macrophage activation, neutrophil movement and osteoclast differentiation.This article reviews the progress of PSTPIP2 in autoinflammatory diseases and its function.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2018-05-18,修回日期:2018-07-10
基金项目:国家自然科学基金资助项目(No 817706609)
作者简介:姚 瑶(1993-),男,硕士生,研究方向:药理学,E-mail:18815517617@163.com;
李 俊(1960-),男,博士,教授,博士生导师,研究方向:抗炎免疫药理学,通讯作者,E-mail:lj@ahmu.edu.cn
更新日期/Last Update: 2018-08-26