[1]申 震,朱付平,黄 勇,等.Wnt/Ca2+信号通路在肢体缺血/再灌注损伤机制中的研究进展[J].中国药理学通报,2018,(10):1344-1347.[doi:10.3969/j.issn.1001-1978.2018.10.004]
　SHEN Zhen,ZHU Fu-ping,HUANG Yong,et al.Research progress of Wnt/Ca2+ signaling pathway in mechanism of limb ischemia/reperfusion injury[J].Chinese Pharmacological Bulletin,2018,(10):1344-1347.[doi:10.3969/j.issn.1001-1978.2018.10.004]
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Wnt/Ca2+信号通路在肢体缺血/再灌注损伤机制中的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年10期
页码:
1344-1347
栏目:
讲座与综述
出版日期:
2018-09-26

文章信息/Info

Title:
Research progress of Wnt/Ca2+ signaling pathway in mechanism of limb ischemia/reperfusion injury
文章编号:
1001-1978(2018)10-1344-04
作者:
申 震1; 朱付平1; 黄 勇2; 范仪铭2; 周富强1; 潘成熙1
1.湖南中医药大学第一附属医院骨科,湖南 长沙 410007; 2.河南省洛阳正骨医院骨科,河南 洛阳 471000
Author(s):
SHEN Zhen1;  ZHU Fu-ping1;  HUANG Yong2;  FAN Yi-ming2;  ZHOU Fu-qiang1;  PAN Cheng-xi1
1.Dept of Orthopedics, the First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410007,China; 2.Dept of Orthopedics, Luoyang Orthopedic Hospital of Henan Province, Luoyang 471000,China
关键词:
Wnt/Ca2+信号通路;  细胞凋亡;  Ca2+超载;  炎症反应;  肢体缺血/再灌注损伤;  病理机制
Keywords:
Wnt/Ca2+ signaling pathway;  apoptosis;  calcium ion overload;  inflammatory response;  limb ischemia/reperfusion injury;  pathological mechanism
分类号:
R-05; R329.25; R348.1; R364.5; R619.9
DOI:
10.3969/j.issn.1001-1978.2018.10.004
文献标志码:
A
摘要:
Wnt/Ca2+信号通路属于Wnt非经典通路,该通路的失调与细胞调亡、炎症反应等病理改变,以及许多疾病的发生、发展、转归有着密切联系。肢体缺血/再灌注损伤(LIRI)是临床工作中常遇到的一类难题,而Wnt/Ca2+通路可诱使细胞内Ca2+浓度升高并可活化Ca2+敏感信号成分,其介导的细胞凋亡、Ca2+超载和机体炎症等反应在LIRI中扮演重要角色。该文就Wnt/Ca2+信号通路在LIRI病机中所起的作用进行综述。
Abstract:
Wnt/Ca2+ signaling pathway is an integrant part of non-canonical Wnt signaling, which is closely related with initiation and progression of many pathological changes including apoptosis, calcium ion overload, inflammation and so on.Limb ischemia/reperfusion injury(LIRI)is common in clinical practice and difficult to deal with.The up-regulation of calcium concentration is induced and components sensitive to calcium are activated by Wnt/Ca2+ pathway.Additionally, Wnt/Ca2+-medicated calcium metabolic process and inflammatory responses are involved with LIRI.Therefore, based on literature review, this present paper summarizes the role of Wnt/Ca2+ pathway in the pathological mechanism of LIRI.

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备注/Memo

备注/Memo:
收稿日期:2018-05-24,修回日期:2018-07-28
基金项目:国家自然科学基金资助项目(No 81674008); 湖南省科技厅资助项目(No 2013FJ4056)
作者简介:申 震(1989-),男,博士生,研究方向:中医药防治骨与关节损伤,E-mail:863491423@qq.com;
朱付平(1968-),男,博士,副教授,硕士生导师,研究方向:中医药防治骨与关节损伤,通讯作者,E-mail:zhufp120@163.com
更新日期/Last Update: 2018-08-26