[1]邹 伟,张婷婷,曹玉珠,等.肿瘤转移前微环境形成机制的研究进展[J].中国药理学通报,2018,(10):1348-1352.[doi:10.3969/j.issn.1001-1978.2018.10.005]
 ZOU Wei,ZHANG Ting-ting,CAO Yu-zhu,et al.Research progress of mechanism of pre-metastatic niches formation[J].Chinese Pharmacological Bulletin,2018,(10):1348-1352.[doi:10.3969/j.issn.1001-1978.2018.10.005]
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肿瘤转移前微环境形成机制的研究进展()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年10期
页码:
1348-1352
栏目:
讲座与综述
出版日期:
2018-09-26

文章信息/Info

Title:
Research progress of mechanism of pre-metastatic niches formation
文章编号:
1001-1978(2018)10-1348-05
作者:
邹 伟1 张婷婷1曹玉珠1李晓曼1吴媛媛1陈文星12陆 茵12王爱云12
南京中医药大学1.药学院,江苏省中药药效与安全性评价重点实验室,2.江苏省中医药防治肿瘤协同创新中心,江苏 南京 210023
Author(s):
ZOU Wei1 ZHANG Ting-ting1 CAO Yu-zhu1 LI Xiao-man1 WU Yuan-yuan1 CHEN Wen-xing12 LU Yin12 WANG Ai-yun12
1.Jiangsu Key Lab for Pharmacology and Safety Evaluation of Chinese Materia Medica, School of Pharmacy; 2.Jiangsu Collaborative Innovation Center of Traditional Chinese Medicine(TCM)Prevention and Treatment of Tumor, Nanjing University of Chinese Medicine, Nanjing 210023, China
关键词:
转移前微环境 肿瘤转移 分子机制 形成因素 演变过程 临床检测
Keywords:
pre-metastatic niches tumor metastatic molecular mechanisms formation factors evolution clinical detection
分类号:
R-05; R329.2; R730.2; R73-37
DOI:
10.3969/j.issn.1001-1978.2018.10.005
文献标志码:
A
摘要:
肿瘤原发灶诱导待转移器官营造一个适宜转移的微环境,即转移前微环境。转移前微环境的形成是一个由多种细胞和细胞因子参与的复杂过程,其中肿瘤衍生因子、肿瘤外泌体以及骨髓源性细胞在转移前微环境形成中至关重要。该文概述了转移前微环境的重要组成因素和主要形成过程的新机制,并探讨可能的临床意义,以期通过阻断转移前微环境的形成,为治疗肿瘤转移提供新思路。
Abstract:
Primary tumors create a favorable microenvironment in pre-metastatic organ for subsequent metastases, namely, pre-metastatic niche.The formation of pre-metastatic niche is a complex process involving multiple cells and cytokines, among which tumor-derived secreted factors, extracellular vesicles and bone marrow-derived cells are of vital importance.This article reviews the major components and the new mechanisms of key processes for pre-metastatic niche formation, and explores the possible clinical significance, in order to provide new ideas for the treatment of metastases by blocking the formation of pre-metastatic niche.

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备注/Memo

备注/Memo:
收稿日期:2018-05-20,修回日期:2018-06-18
基金项目:国家自然科学基金资助项目(No 81573859,81673725); 江苏省高校自然科学研究重大项目(No 17KJA360003)
作者简介:邹 伟(1994-),女,硕士生,研究方向:中药抗肿瘤药理学,E-mail:731239496@qq.com;
王爱云(1974-),女,博士,副教授,硕士生导师,研究方向:活血化瘀中药对肿瘤转移的影响,通讯作者,Tel:025-85811237,E-mail:way9815@163.com
更新日期/Last Update: 2018-08-26