[1]谯 凤,徐慧琴,汪 会,等.18F-FLT micro PET/CT显像评估马蔺子素对裸鼠乳腺癌的放射增敏作用[J].中国药理学通报,2018,(10):1430-1433.[doi:10.3969/j.issn.1001-1978.2018.10.020]
 QIAO Feng,XU Hui-qin,WANG Hui,et al.18F-FLT micro PET/CT imaging evaluation of radiosensitization of MDA-MB231 breast cancer in nude mice[J].Chinese Pharmacological Bulletin,2018,(10):1430-1433.[doi:10.3969/j.issn.1001-1978.2018.10.020]
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18F-FLT micro PET/CT显像评估马蔺子素对裸鼠乳腺癌的放射增敏作用()
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《中国药理学通报》[ISSN:/CN:]

卷:
期数:
2018年10期
页码:
1430-1433
栏目:
论著
出版日期:
2018-10-26

文章信息/Info

Title:
18F-FLT micro PET/CT imaging evaluation of radiosensitization of MDA-MB231 breast cancer in nude mice
文章编号:
1001-1978(2018)10-1430-04
作者:
谯 凤徐慧琴汪 会余文静张 丹苏晓雨
安徽医科大学第一附属医院核医学科,安徽 合肥 230022
Author(s):
QIAO Feng XU Hui-qin WANG Hui YU Wen-jing ZHANG Dan SU Xiao-yu
Dept of Nuclear Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
关键词:
乳腺肿瘤 18F-氟脱氧胸苷 micro PET/CT 马蔺子素 放射增敏 细胞增殖抗原Ki-67
Keywords:
breast neoplasms 18F-FLT micro PET/CT irisquinone radiosensitization cell proliferation antigen Ki-67
分类号:
R-332; R284.1; R392.11; R73-354; R737.905; R814.42; R981.1
DOI:
10.3969/j.issn.1001-1978.2018.10.020
文献标志码:
A
摘要:
目的 利用18F-FLT micro PET/CT显像评估马蔺子素(IR)对裸鼠MDA-MB231乳腺癌的放射增敏作用。方法 32只裸鼠建立MDA-MB231乳腺癌模型,随机分为对照组、IR组、单纯放疗组、IR+放疗组,每组8只。分别在放疗前及放疗后24 h,行18F-FLT micro PET/CT显像,观察4组肿瘤SUVmax的变化。免疫组织化学法分析Ki-67的表达情况。结果 放疗前,4组显像SUVmax差异无统计学意义(P>0.05); 放疗后24 h,对照组及IR组SUVmax较治疗前显像升高(P<0.05),单纯放疗组和IR+放疗组显像SUVmax较治疗前显像下降(P<0.05),且IR+放疗组较单纯放疗组下降更明显(P<0.05); 免疫组化结果显示,放疗组和IR+放疗组中Ki-67阳性表达均明显低于对照组(P<0.05)。Ki-67表达与SUVmax呈明显正相关(r=0.897,P<0.05)。结论 IR对裸鼠乳腺癌具有放射增敏作用,18F-FLT micro PET/CT可以评估IR对裸鼠乳腺癌的放射增敏作用。
Abstract:
Aim To study 18F-FLT micro PET/CT imaging for the evaluation of irisquinone(IR)radiosensitizing effect on MDA-MB231 breast cancer in nude mice.Methods The 32 MDA-MB231 breast cancer model in nude mice was established and randomly divided into control group, IR group, radiotherapy group and IR+radiotherapy group.18F-FLT micro PET/CT imaging was performed before and 24 h after radiotherapy respectively, and the changes of four groups of tumor SUVmax were observed.The expression of Ki-67 was analyzed by immunohistochemistry.Results Before radiotherapy, there was no statistically significant difference in SUVmax among the four groups(P>0.05).24 h after radiotherapy, SUVmax in control group and IR group increased significantly(P<0.05), while SUVmax in radiotherapy group and IR+radiotherapy decreased(P<0.05), and IR+radiotherapy group decreased more significantly than radiotherapy group(P<0.05).The immunohistochemical results showed that the positive expression of Ki-67 in radiotherapy group and IR+radiotherapy group was significantly lower than that in control group(P<0.05).The expression of Ki-67 was positively correlated with SUVmax(r=0.897, P<0.05).Conclusions IR has radiosensitizing effect on breast cancer in nude mice.18F-FLT micro PET/CT can evaluate the radiosensitization effect of IR on breast cancer in nude mice.

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备注/Memo

备注/Memo:
收稿日期:2018-06-10,修回日期:2018-07-12
基金项目:安徽省科技厅科技攻关项目(No 1704a0802164)
作者简介:谯 凤(1991-),女,硕士生,研究方向:放射增敏,E-mail:ayqiaofeng@163.com;
徐慧琴(1965-),女,博士,教授,主任医师,博士生导师,研究方向:放射增敏,通讯作者,E-mail:hfxuhuiqin@163.com
更新日期/Last Update: 2018-08-26